ICAM1 and Alzheimer disease: We found that transient depletion of Tregs resulted in elevated mRNA expression levels of leukocyte trafficking molecules by the CP of AD-Tg/DTR+ mice, relative to DTx-treated AD-Tg/DTR− littermates (Fig. 2a), and immunohistochemistry confirmed elevated ICAM-1 immunoreactivity (Fig. 2b).