Immunohistochemical analysis of the CP, in the weekly GA-treated AD-Tg mice, confirmed increased levels of epithelial ICAM-1 (Fig. 3e), and showed altered epithelial tight junction organization (Supplementary Fig. 3a), previously associated with CNS-infiltrating mo-MΦ trafficking through the CP-CSF migratory pathway17, 18, 20. The gene discussed is CP; the disease is Alzheimer disease.