CXCL10 and Alzheimer disease: We found that along the progressive stages of disease pathology, the CP of AD-Tg mice, compared with age-matched wild-type (WT) controls, expressed significantly lower levels of leukocyte homing and trafficking determinants, including intercellular adhesion molecule 1 (icam1), vascular cell adhesion molecule 1 (vcam1), C-X-C motif chemokine 10 (cxcl10) and chemokine C-C motif ligand 2 (ccl2) (Fig. 1a), shown to be upregulated by the CP in response to acute CNS damage and needed for transepithelial migration of leukocytes17, 18, 19.