Notably, we found elevated levels of Foxp3+ Treg along disease progression in splenocytes of 5XFAD AD-Tg mice, relative to age-matched WT littermates (Supplementary Fig. 1a,b), in line with reports of elevated Treg levels and their suppressive activities in AD patients28, 29, 30. Here, FOXP3 is linked to Alzheimer disease.