Examining the CP of 5XFAD AD-Tg mice using intracellular staining followed by flow cytometry, revealed significantly lower numbers of IFN-γ-producing cells in this compartment (Fig. 1e), and quantitative real-time PCR (RT-qPCR) analysis confirmed lower mRNA expression levels of ifn-γ at the CP of AD-Tg mice compared with age-matched WT controls (Fig. 1f). Here, CP is linked to Alzheimer disease.