After ethanol feeding the ALDH2-knockout mice had lower hepatic SREBP-1c levels and a lower degree of hepatic steatosis than wild-type mice [31], although an in vitro study in rat hepatoma cell lines showed that cyanamide, an ALDH inhibitor, increased the effects of ethanol on the up-regulation of SREBP-1c [28]. This evidence concerns the gene LDHA and fatty liver disease.