CASC2 and polycystic ovary syndrome: The Stage 1 Discovery GWAS for reproductive hormone levels within the PCOS cases (N=645–957 depending on hormone trait) identified three loci reaching genome–wide significance: the 7q33 DGKI locus with total T levels, linear regression P=1.3 × 10−8; the 10q26.11 CASC2 locus with FSH levels, linear regression P=3.2 × 10−8; and the 11p14.1 FSHB/ARL14EP locus with LH levels, linear regression P=1.8 × 10−9 (Table 2; Figs 1b and 2d; Supplementary Data 1, 2, Supplementary Figs 2–5).