The same 11p14.1 FSHB/ARL14EP SNP, rs11031006, that was most strongly associated with PCOS reached genome-wide significance with LH in the Stage 1 Discovery GWAS (G allele, Beta=3.19, 0.53 s.e., mIU ml−1, linear regression P=1.8 × 10−9) and was nominally significant in the Stage 2 Metabochip Replication (G allele, Beta=2.19, 0.65 s.e., mIU ml−1, linear regression P=7.7 × 10−4) for a sample-size weighted two-strata meta-analysis Pmeta=8.5 × 10−12. This evidence concerns the gene FSHB and polycystic ovary syndrome.