Adjusting for LH levels in the regression model between rs11031006 and PCOS negated the association (OR=1.18, 1.02–1.37 95%CI, P=6.3 × 10−3 without LH in the model; OR=1.55, 1.01–2.39 95%CI, P=0.66 with LH in the model; Supplementary Data 7), suggesting that the association with FSHB is mediated by LH. This evidence concerns the gene PLOD1 and polycystic ovary syndrome.