The Chinese GWAS findings of associations with the genes encoding gonadotropin receptors, LHCGR and FSHR, suggest that ovarian gonadotropin action plays a role in all of the Rotterdam phenotypes, while our findings of associations of FSHB with PCOS and LH levels suggest that gonadotropin secretion drives the accompanying hormonal derangements of hyperandrogenism and anovulation. Here, LGR6 is linked to polycystic ovary syndrome.