Three loci reached genome-wide significance in the PCOS case–control meta-analysis, two novel loci, chr 8p32.1 GATA4/NEIL2 and chr 11p14.1 FSHB/ARL14EP, and a chr 9q22.32 c9orf3/FANCC locus previously found in Chinese PCOS. The gene discussed is AOPEP; the disease is polycystic ovary syndrome.