GATA4 and polycystic ovary syndrome: The 8p32.1 PCOS locus spanned a 6.6 region of extensive linkage disequilibrium (r2>0.2) including the 3′ end of GATA4 and all of NEIL2 into the intergenic region before FDFT1. The most strongly associated SNP (rs804279) was intergenic, approached genome-wide significance in the Stage 1 Discovery GWAS (A allele, OR=0.74, 0.66–0.83 95%CI, logistic regression P=1.4 × 10−6), and was nominally significant in the Stage 2 Metabochip Replication (A allele, OR=0.82, 0.73–0.93 95%CI, logistic regression P=2.7 × 10−3) for a sample-size weighted two-strata meta-analysis Pmeta=1.9 × 10−8.