LRP4 and amyotrophic lateral sclerosis: Nevertheless, while this manuscript was in preparation, Tzartos and coworkers reported a high and persistent frequency of anti-LRP4 abs in the sera (23.4%) and cerebrospinal fluid of patients with amyotrophic lateral sclerosis suggesting that LRP4 autoimmune reactivity may be more widely related to damage of LRP4 expressing tissues such as NMJ but also motor neurons and brain.