MPL and immune system disorder: For Thrombocythemia, the three known disease genes TPO, JAK2 and MPL can thoroughly perturb some common ranges which have the same biological functions, such as JAK-STAT cascade, growth hormone receptor signaling pathway, cytokine-mediated signaling pathway, etc. For Immunodeficiency, its known disease genes CD3E and CD3G almost have the same perturbation influences on the regulatory network, which chiefly affect the immune response of human.