BACE1 and early-onset autosomal dominant Alzheimer disease: For instance, Kanekiyo et al. [31] have demonstrated that the low-density lipoprotein receptor-related protein 1 (LRP1) plays a critical role in brain amyloid-β (Aβ) peptides clearance and the Accumulation, aggregation, and deposition of Aβ are likely initiating events in the pathogenesis of Alzheimer’s disease (AD); Protein precursor cleaving enzyme 1 (BACE1) is the first protease and the rate limiting enzyme in the genesis of amyloid-β.