To begin to address this question and extend technical validations to in vivo and functional levels, five AEU events that were identified through exon-microarrays, including mRNA from the TET2 gene and four ATP transporters, were analyzed in detail in AML cell lines as well as in bone marrow samples derived from 152 AML and 37 normal bone marrow samples. This evidence concerns the gene TET2 and acute myeloid leukemia.