ABCA3 and cancer: In addition to ABC-B1 (MDR1/Pgp)-mediated chemoresistance [33, 34], genetic polymorphisms [35] as well as functional [36] and transcriptional [37] analyses have shown that an increasing number of ABC transporters, including ABC-A3, ABC-C1, ABC-C3 and ABC-G2, can cause resistance to cancer chemotherapeutic agents [3, 38–40].