However, the response to GDC-0980 was not affected by the ablation of Bim and Bid, key BH3-only proteins of the intrinsic and extrinsic apoptotic pathways respectively, which we previously found to be required for the apoptotic response of mesothelioma [1, 25, 27, 28](Fig 4B). This evidence concerns the gene BID and mesothelioma.