Interestingly, in an independent study in hematopoietic cancer, the combination of JQ1 affecting the c-Myc levels and a FLT3 tyrosine kinase inhibitor (TKI) was synergistic in overcoming resistance to the FLT3 TKI in acute myeloid leukemia (AML) cells (Fiskus et al., 2014). Here, MYC is linked to acute myeloid leukemia.