NTRK1 and melanoma: Based on similar logic, other plausible therapeutic combinations that target particular escape routes in RAFi-resistant melanomas have been put forward, including combinations that target downstream elements of the ERK pathway (e.g., RAFi + MEKi) (Lito, Pratilas et al., 2012; Flaherty et al., 2012a), or upstream receptor tyrosine kinases (Prahallad et al., 2012; Sun et al., 2014).