Results showed the increased concentrations of total IgG [HC vs. Sj: mean = 359.7, 95% confidence interval (95% CI) = 343.6–375.7 vs. mean = 417.9, 95% CI = 398.2–437.5; p<0.001] and IgE antibodies (HC vs. Sj: mean = 10.6, 95% CI = 9.5–11.7 vs. mean = 38.6, 95%CI = 30.5–46.7; p<0.001) in schistosomiasis patients (Fig 4A and 4C). Here, IGHE is linked to schistosomiasis.