In the first miRNA signature, the levels of five miRNAs (miR-512-3p, miR-886-5p, miR-886-3p, miR-708, miR-135b) are up-regulated, and levels of two miRNAs (miR-146a, miR-155) are down-regulated as compared to ALCL/ALK+ disease group from ALCL/ALK−, and other PTCLs disease group (73). The gene discussed is ALK; the disease is anaplastic large cell lymphoma.