MiR-15b, miR-130b, and miR-16 are potential, specific diagnostic markers in discriminate between HCC and HBV hepatitis patients, and for early detection of liver cancer as compared to others serum cancer biomarkers such as AFP, des-γ-carboxyprothrombin (DCP), and AFP-L3 (31, 32). The gene discussed is AFP; the disease is cancer.