Additionally, a combination of four miRNAs (miR-19b, miR-23b, miR-26a, and miR-92a) was found to regulate PTEN expression post-transcriptionally and to affect the downstream PI3K/Akt pathway via PIK3CA (p110α), PIK3CD (p110δ), PIK3R1 (p85), Akt, and cyclin D1, thus promoting prostate cancer cells proliferation in vitro (98). This evidence concerns the gene PIK3CA and Familial prostate cancer.