The role of impaired glucose metabolism in cancer development and survival has been suggested [64], for instance, Hammarsten et al showed in a prospective study of 320 prostate cancer patients that men who died of clinical prostate cancer during follow-up had a higher prevalence of type 2 diabetes (P < 0.035) and higher levels of fasting plasma insulin (P = 0.004) [65]. Here, INS is linked to cancer.