STK11 and cancer: The involvement of the AMP-activated kinase AMPK has been the subject of extensive research in the last decade (reviewed in [71]), because of its central role in regulating the balance between anabolic and catabolic metabolism based on cellular energy state [72] and its involvement in cancer, either through direct alterations (rare) or loss of function of its regulator LKB1 (also known as STK11, long known to cause the hereditary Peutz-Jaeghers cancer syndrome) [73].