Earlier, we have shown three regulatory genes, viz. chemokine (C–C motif) receptor 1 (CCR1), macrophage scavenger receptor 1 (MSR1) and spleen focus forming virus proviral integration oncogene (SPI1) associated with diseases like obesity and osteoporosis using gene network algorithms WGCNA and Lemon-Tree (Kogelman et al., 2014) applied to NGS-based RNA-Seq datasets from porcine model for obesity (see RNA-Seq web reference1). The gene discussed is SPI1; the disease is obesity due to melanocortin 4 receptor deficiency.