By the pathway analysis in the KEGG database, we found that seven genes (CEBPA, SMAD3, GSK3B, LAMC2, MMP1, PIK3R3, and RXRA) in this DNB module participate in cancer pathways, and many genes of this module also take part in other cancer-related pathways, e.g., the Wnt signaling pathway with P-value (9.10E-03), the p53 signaling pathway with P-value (1.10E-04), and the ECM-receptor interaction with P-value (2.30E-03). Here, SMAD3 is linked to cancer.