CD1D and Gaucher disease: In PBMC of healthy individuals, approximately 0.5% of CD3+ lymphocytes stained with β-GlcCer/CD1d tetramers, similar to numbers in Gaucher’s disease patients, whereas 1–2% of CD3+ lymphocytes in these patients stained positive with β-GlcSph/CD1d tetramers, compared to 0.2% in healthy individuals (57).