PTGS2 and arthritic joint disease: Celecoxib, a classical Non-steroidal anti-inflammatory drug (NSAID) and inhibitor of the enzyme COX2, has been widely used as an anti-inflammatory drug for the treatment of acute pain, arthritis, menstrual pain, and discomfort (Tindall, 1999; Bensen, 2000; Kumar et al., 2013).