Phenocopying L-SACC1 mice with liver-specific inactivation of CEACAM1 and global Cc1−/− null mice (1–3), HF diet represses hepatic CEACAM1 levels to impair insulin clearance and cause hyperinsulinemia, which in turn, activates de novo lipogenic pathways and elevates lipid production in liver (7). Here, INS is linked to hyperinsulinism.