Blockade of CXCR4 signaling, and elevation of cAMP levels, with specific small molecule antagonists has potent anti-tumor effects in intracranial xenograft models of SHH driven medulloblastoma (Rubin et al., 2003; Yang et al., 2007; Barone et al., 2014). The gene discussed is CXCR4; the disease is medulloblastoma.