Among all pH regulators, the Na+/H+ exchanger type 1 (NHE1) has drawn a lot of attention because it is overexpressed and over-activated in cancer cells (Gatenby et al., 2007), and its activity is associated with cancer cell survival, migration and metastatic progression (Cardone et al., 2005; Brisson et al., 2012). Here, SLC9A1 is linked to cancer.