PPARD and breast cancer: Another way to regulate the aggressivity of breast cancer cells could be the transcriptional inhibition of NaV1.5 expression in breast cancer cells by n-3 polyunsaturated long chain fatty acids coming from the diet, such as docosahexaenoic acid (C22:6n-3) (Isbilen et al., 2006; Gillet et al., 2011), that was recently identified as being mediated by the lipid-sensitive transcription factor Peroxisome Proliferator Activated Receptor (PPAR)-β (Wannous et al., 2015).