The activity of NaV1.6 channels in the plasma membrane of cervical cancer cells was confirmed using the NaV1.6-specific toxin Cn2 (1 μM) which blocked ~50% of the sodium current in patch-clamp experiments, and reduced by ~20% cell invasiveness of primary-cultured cervical cancer cells, without affecting cell proliferation or migration. Here, SCN8A is linked to cervical cancer.