The relative mRNA expression, analyzed by RT-PCR, was found higher for NaV1.1, NaV1.3, NaV1.4, and NaV1.5 in ovarian cancers cells compared with normal ovarian tissues, and the mRNA expression of NaV1.2, NaV1.4, NaV1.5, and Nav1.7 was also significantly increased in highly invasive ovarian cancer cells Caov-3 and SKOV-3, compared with the weakly invasive Anglne ovarian cancer cells, while the expression of mRNA for other NaVα was not significantly different. This evidence concerns the gene SCN9A and ovarian cancer.