SIRT1 and Cognitive impairment: Our previous studies demonstrated that EA at Dazhui (GV14) and Shenshu (BL23) in SAMP8 mice improves cognitive deficits, activates AMP-activated protein kinase (AMPK), and upregulates Sirtuin 1 (SIRT1)-dependent peroxisome proliferator- activated receptor-γ co-activator-1α (PGC-1α) expression (Dong et al., 2015).