CXCL8 and myeloid sarcoma: Firstly, supernatants from unstimulated PBMCs isolated from RR-MS patients displayed enhanced TNF-α (Figures 4A,C) and IL-8 (Figures 4B,D) expression, when compared to PBMCs from healthy subjects, indicating the RR-MS patient PBMCs display an enhanced endogenous inflammatory signature.