KIRREL3 and brain disorder: However, the potential role of Neph2 in synapse development has not been explored, except for the finding that Neph2 directly interacts with CASK (Gerke et al., 2006), a synaptic scaffolding protein implicated in synapse development and brain disorders such as X-linked microcephaly and intellectual disability (ID; Hsueh, 2006, 2009; Moog et al., 2011).