Unlike MS, which is a spontaneous disease of unknown etiology, EAE is induced by immunizing animals (most commonly mice) with myelin or myelin components, such as proteolipid protein (PLP), myelin basic protein (MBP) or myelin oligodendrocyte glycoprotein (MOG) (Merrill et al., 1992; Baxter, 2007). Here, MOG is linked to myeloid sarcoma.