MAPT and Alzheimer disease: Finally, an interesting rat model produces all of the hallmarks of AD pathology, such as hippocampal dependent memory impairments, amyloid plaque deposits, hyperphosphorylated tau protein, and neurofibrillary tangles via chronic injections of a solution consisting of Aβ1−42, and the pro-oxidative inducing agents: ferrous sulfate and buthionine sulfoximine (Lecanu and Papadopoulos, 2013).