Vitamin D supplementation has also been associated with a decreased Th17-to-Tregulatory lymphocyte ratio [43], decreased expression of CD38+ and Ki67+ on memory CD8+ T lymphocytes [45], increased regulatory T lymphocyte numbers [43, 46], enhanced Th2-dependent cytokine expression and decreased Th1-dependent cytokine levels [47], which may help to limit ongoing immune activation in settings such as treated HIV infection. This evidence concerns the gene CD8A and HIV infectious disease.