While positive results have been reported for JAK-STAT inhibition in preclinical GBM models, no human glioma JAK-STAT inhibitor based clinical studies have yet been performed, although one trial for a small molecule JAK-STAT inhibitor, WP1066, is pending (U.S. National Clinical Trials Database—https://clinicaltrials.gov/) [8–10]. Here, SOAT1 is linked to central nervous system cancer.