SOAT1 and glioblastoma: Here we report initial steps to address the following hypotheses; (1) that SAR317461 can overcome and kill immortalized, serum dependent GBM cell lines, as well as human GBM stem cell (GSC) derived tumorspheres that exhibit the genotypic and phenotypic heterogeneity of the human disease, (2) that the general mechanism of SAR317461 induced GBM cell death is apoptosis, (3) that sensitivity of GBM to SAR317461 depends on the presence of an activated JAK-STAT pathway, and (4) that inhibition of other survival mechanisms, specifically autophagy, may increase the potency of SAR317461.