To estimate the predictive power of each biomarker, we performed NRI and IDI analyses for early AKI and determined the NRI for urinary KIM-1 to be 0.9307 (standard error [SE] = 0.3206, z = 2.9027, p = 0.0037), and for urinary IL-18 to be 0.9069 (SE = 0.3206, z = 2.8284, p = 0.0047). This evidence concerns the gene IL18 and acute kidney injury.