EIF2A and neoplasm: Based on these findings and the aforementioned in vitro analyses, we interpret the role of OLA1 in tumor growth as follows (Fig. 8B,C): under intratumoral stresses, interaction of OLA1 with eIF2, which suppresses TC formation, and phosphorylation of eIF2α, which blocks TC regeneration, are co-induced to deplete TC and activate ISR.