SEMA4C and breast cancer: So we also tested the role of GIT1 in NSCLC EMT and found that GIT1 functioned as SEMA4C did, which indicated that GIT1 may be a critical protein modulating invasion and metastasis in the progress of many cancers, such as oral squamous cell carcinoma, breast cancer and NSCLC 26, 27, 30, 31.