Given that chronic inflammation in epithelial tissues predisposes to cancer development (Mantovani et al, 2008), the finding that the mutagenic activity of AID can be induced in an inflammatory context has fostered the idea that AID might contribute to or even constitute the link between inflammation and cancer (Takai et al, 2012; reviewed in Marusawa et al (2011)). This evidence concerns the gene AICDA and cancer.