Collectively, we believe that NR2B-mediated signaling pathway may represent a novel approach to modulating cortical plasticity, and magnesium supplementation should be investigated further to develop a convenient and plasticity-based treatment for several human brain disorders, such as amblyopia, aphasia, schizophrenia and stroke [40, 43, 72, 73]. The gene discussed is GRIN2B; the disease is Aphasia.