To further examine the contributions of the NR2A and NR2B subunits, we locally infused the NR2A antagonists PPPA or TCN 201, the NR2B antagonist Ro 25-6981, or vehicle into the visual cortex of magnesium-treated mice using an osmotic minipump one day prior to and throughout 4 days of MD (Fig. 2b). The gene discussed is GRIN2A; the disease is Menkes disease.