AKT1 and plasma cell myeloma: Our modeling analysis indicated that in the presence of OCs (1) the growth and proliferation-associated signaling pathways were activated, including PI3K/AKT and MEK/ERK, and apoptotic regulatory proteins, BAX and BIM, down-regulated under normoxic condition; (2) β1 Integrin/FAK signaling pathway was activated in myeloma cells under hypoxic condition.