CD4 and tuberculosis: A composite factor of high HIV viral loads ≥ 100,000 copies/mL or low CD4 cell counts of < 350 cells/μL (adjusted HR 4.7, 95% CI 1.49–15.90, p = 0.009) and a positive IGRA in those lacking the composite factor (adjusted HR 6.09, 95% CI 1.52–24.40, p = 0.01) were two independent risk factors for developing incident active TB (Table 3 and Fig 4).