Intriguingly, however, in these tumours, high expression of TLX in the absence of ERα is related to better survival, as seen in ERα-negative (HR = 0.69 (0.48 – 0.99), p = 0.048) and the PAM50 basal subtype (HR = 0.58 (0.37 – 0.93), p = 0.023). This evidence concerns the gene ESR1 and neoplasm.