NFE2L2 and neoplasm: Nrf2 activity has been labeled a “double-edged sword” with both anti- and pro-tumorigenic properties, which can be both beneficial and deleterious: on the one hand, Nrf2 protects normal cells from oxidative stress and confers protection against tumorigenesis, while, on the other hand, it promotes ROS detoxification and tumor cell proliferation [7].