SOD1 and amyotrophic lateral sclerosis: IL-10 has pleiotropic effects on immunoregulation.28 IL-4 is a Th2-associated cytokine.27 Eotaxin/CCL11 is a potent eosinophil chemoattractant cytokine associated with allergic airway inflammation.29 Thus, our results are consistent with the findings in SOD1 mouse models, in which regulatory T and Th2 cells can be beneficial.27 Furthermore, G-CSF was elevated in patients with motor neuron disease (PMA and ALS) compared with patients with MMN and disease controls.