CD274 and non-small cell lung carcinoma: However, analyzing on the basis of currently available clinical and basic studies, it can be assumed that different responses to anti-PD-1/PD-L1 therapy are not caused by single factors, but the result of the interaction of various factors (different PD-1 SNP statuses, genetic mutations , PD-L1 expression, histopathologic types of NSCLC and so on).