CENPF and Cyclin B1 are two important FOXM1 targets that mediate the mitosis-regulatory effects of FOXM1.20, 21 Furthermore, FOXM1 and CENPF were recently shown to have a synergistic interaction that drives cancer malignancy.22 Therefore, we used CENPF and Cyclin B1 as markers for FOXM1 activity. The gene discussed is CCNB1; the disease is cancer.