Faithfully mimicking natural development of melanoma in mice is still an ongoing task as there are notable differences in melanoma development in humans and mice and mice generally express less cutaneous melanocytes.36, 37 Recent advances have been made in generating inducible BRAFV600E mice either in combination with PTEN loss.38, 39 Targeting proteins in mice, however, requires a high degree of sequence homology, which is sometimes absent. Here, PTEN is linked to melanoma.