In melanomas, including the cell line used here, however, expression of the CDKN2A locus is frequently lost (see Figure 1c).15 This still results in excessive expression of FOXM1 in melanomas (Figures 2a and f) and the here used CDKN2A-deficient cells (Figures 5a and c), indicating that ARF1 expression is not critical to FOXM1 expression in CDKN2A-depleted melanomas and FOXM1 inhibition cannot be targeted this way. The gene discussed is CDKN2A; the disease is melanoma.