Shoamanesh et al. [15] found no association between some inflammatory biomarkers (including CRP, IL-6 and TNF) and SVD (defined as presence of silent infarcts and/or extensive WMH) in a large cohort of younger stroke-free Framingham participants (n = 522; mean age 60 years) but did associate ICAM with SVD. This evidence concerns the gene CRP and stroke disorder.