However, Rouhl et al. [39] found no difference in CRP levels between 81 patients with and 265 patients without extensive WMH, Wersching et al. [13] found no association between CRP and WMH among 321 older stroke-free participants, Baune et al. [40] found no association between TNF and WMH among 268 community-dwelling participants and Aribisala et al. [41] found no association between inflammation (a latent factor comprising CRP, fibrinogen and IL-6) and WMH among 634 community-dwelling older people of near-identical age. This evidence concerns the gene TNF and stroke disorder.