CDKN1A and cancer: Some authors suggest that the 3’ polymorphism may increase the risk of cancer by altering mRNA stability and, in doing so, increase intracellular levels of CDKN1A21, and others observed a linkage disequilibrium between rs1059234 and other p21 polymorphisms, namely rs1801270 at codon 31 and rs3176352 in an intron, which have been functionally associated with CDKN1A function and gene expression levels19, 37.