One of the first adjuvant trials evaluating doxorubicin was NSABP B-11, which compared melphalan and 5-fluorouracil with or without doxorubicin in 697 non-tamoxifen responsive patients (defined as women 50–59 years with a tumor PR level by ligand binding assay of 0–9 fmol, and all patients ≤49 years), and found an improved 5-year DFS (HR, 0.65; P = 0.007) and a trend to improved OS (HR, 0.74; P = 0.08) for the doxorubicin arm [72]. Here, PGR is linked to neoplasm.