The TGF-β1–dependent increase in αSMA expression was dose dependently inhibited in both NFC- and IPF-derived HLMFs by LXA4 at 10−10 mol (p = 0.0106) and 10−8 mol (p = 0.0076) (Fig. 4A, 4B). Here, ACTA1 is linked to idiopathic pulmonary fibrosis.