This TGF-β1–dependent αSMA mRNA expression was significantly reduced in IPF-derived HLMFs following treatment with LXA4 at 10−10 and 10−8 mol (p = 0.0479 and p = 0.0033, respectively, two-way ANOVA) (Fig. 4D), but not NFC-derived cells. The gene discussed is ACTA1; the disease is idiopathic pulmonary fibrosis.