MAPT and tauopathy: We demonstrate that widespread expression of human tau was detected in mice injected with AAV1-TauP301L, leading to the accumulation and deposition of hyperphosphorylated and abnormally folded tau species in NFTs and neuritic inclusions, which are also detected with Gallyas silver stain and Thioflavin S. Perhaps most importantly, the tau pathology produced by the expression of AAV1-TauP301L recapitulates human tauopathies at the ultrastructural level as indicated by the presence of pre-tangles, mature neurofibrillary tangles, neuropil threads and dystrophic neurites.