Abnormal deposition of the tau protein is the hallmark feature of tauopathies, which encompasses a growing list of neurodegenerative diseases, including Alzheimer's disease (AD), frontotemporal dementia (FTD), progressive supranuclear palsy, corticobasal degeneration (CBD) and chronic traumatic encephalopathy (CTE). This evidence concerns the gene MAPT and neurodegenerative disease.