The fact that tau pathology and tauopathy-associated behavioral abnormalities appear to occur independently of neuronal loss in our AAV-based model is in agreement with reports in other tau models, including the rTg4510 and humanized tau mouse models (50,51), although future studies will need to assess whether neuronal loss is observed in the AAV1-TauP301L model beyond 6 months of age. Here, MAPT is linked to tauopathy.