Here, although the specific biological role of PCDH10 in NSCLC still needs to be elucidated, we showed that PCDH10 promoter methylation predicted a poor prognosis in patients with curatively resected pathological stage I NSCLC by performing Kaplan–Meier survival analysis and log-rank testing. Here, PCDH10 is linked to non-small cell lung carcinoma.