C-reactive protein has been generally considered a minor APP in bovine due to minimal changes observed in its concentrations in serum of cattle during inflammatory conditions [29], however studies have demonstrated its potential as a parameter of mastitis in milk [30–32] but insufficient data exists on the profile of CRP in healthy versus mastitis milk and on the correlation of CRP with other mastitis parameters, notably SCC and milk APP. Here, CRP is linked to mastitis.