Furthermore, in their analysis of mouse prostate and human bladder cancer samples, high expression of NEDD4 was inversely correlated to PTEN protein levels but not PTEN mRNA levels, suggesting that NEDD4 plays a proto-oncogenic role in tumorigenesis and cancer development via post-translational suppression of PTEN [14]. This evidence concerns the gene NEDD4 and urinary bladder carcinoma.