YKL-40, a member of mammalian chitinase-like proteins, is overexpressed in many pathological conditions that includes fibroblastic change in liver cirrhosis, increased deposition of connective tissue components and hyperplastic synovium in rheumatoid arthritis, and increased cellular infiltration as well as epithelial proliferation in chronic colitis [4]. Here, CHI3L1 is linked to rheumatoid arthritis.