To investigate the correlation between YKL-40 and EMT related-genes for promoting migration/invasion capability of NSCLC, several EMT-associated genes such as adhesion markers E-cadherin and N-cadherin; transcription regulators Twist, Snail and Slug; and cytoskeleton organization marker Vimentin in YKL-40 overexpressed-CL 1–1 and YKL-40 knockdowned-CL 1–1 (Fig. 4) were analyzed. Here, CHI3L1 is linked to non-small cell lung carcinoma.