Five genes (VEGFA, IFNB1, IGF1, TEK, and TGFBR1) are associated with angiogenesis, which provides clues to the mechanism of the association between epigenetic inactivation of CYB5R2 and lymph node metastasis [10]. Here, CYB5R2 is linked to metastatic malignant neoplasm in the lymph nodes.