We found that CYB5R2 expression in NPC cells altered the angiogenic balance by down-regulating a series of angiogenesis-promoting factors (VEGFA, IGF1, TGFBR1, and TEK) and up-regulating an angiogenesis inhibitor, IFNB1. This evidence concerns the gene TGFBR1 and nasopharyngeal carcinoma.