IFT27 and short rib-polydactyly syndrome: Those four components are IFT80, IFT88, IFT172 and very recently IFT27.3–6 Defects in any of them result in short rib-polydactyly syndromes, Jeune asphyxiating thoracic dystrophy, Mainzer-Saldino syndrome, or a reno-oculo-hepatic ciliopathy with polydactyly (Bardet-Biedl syndrome, MIM 209900), in the case of IFT27.